PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration)
PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) was first identified in 2015 by researchers at the University of Birmingham. New research published in Cell Reports Medicine demonstrates for the first time that PEPITEM could be utilized as a novel early clinical intervention to mitigate the effects of age-related musculoskeletal diseases. The data indicates that PEPITEM enhances bone mineralization, formation, and strength, effectively reversing bone loss in animal models.
Bone Anatomy
This research was supported by significant grants from the Medical Research Council and the Lorna and Yuti Chernajovsky Biomedical Research Foundation, which invests in research for developing new targeted medicines to improve health outcomes. Additional funding was provided by the British Society for Research on Ageing and Versus Arthritis.
Bone undergoes constant formation, reformation, and remodeling throughout life, with up to 10% of human bone being replaced annually. This process involves a complex interplay between osteoblasts, which form bone, and osteoclasts, which break down bone. Disruptions to this finely tuned process are responsible for diseases such as osteoporosis and rheumatoid arthritis, characterized by excessive bone breakdown, or ankylosing spondylitis, marked by abnormal bone growth.
