One of the most intriguing aspects of Klotho is its association with aging. Klotho-deficient mice exhibit a spectrum of aging-related phenotypes, including vascular calcification, osteoporosis, cognitive decline, and reduced lifespan. Conversely, Klotho overexpression extends lifespan and mitigates age-related pathologies. The exact mechanisms by which Klotho influences aging are complex and multifactorial, involving oxidative stress, inflammation, and cellular senescence.
Klotho QT Prolongation
Klotho and Aging: The image illustrates the impact of FGF23 and klotho on heart health in CKD contexts. On the left, high FGF23 levels in dialysis patients and mice lead to Long QT Syndrome, marked by elongated QT intervals on ECGs, due to reduced Kv4.2 channel expression. On the right, increased klotho availability, either through treatment or genetic modification, prevents Long QT Syndrome, maintaining normal Kv4.2 channel expression and ECG patterns.
